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<div>Prader-Willi syndrome(PSW) is a rare genetic disorder that causes characteristics such as obesity due to an excessive appetite. ;</div>
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<p><a href="https://lh5.googleusercontent.com/-2saXLvsmX_c/UYQ1BNW0weI/AAAAAAAACAo/aVuN0vdRTMI/s640/blogger-image-290728310.jpg" style="margin-left: 1em; margin-right: 1em;"><img loading="lazy" border="0" height="320" src="https://lh5.googleusercontent.com/-2saXLvsmX_c/UYQ1BNW0weI/AAAAAAAACAo/aVuN0vdRTMI/s400/blogger-image-290728310.jpg" width="400" /></a></p>
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<div><b> ;Signs and Symptoms</b></div>
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<li>Newborns are often small and floppy.</li>
<li>Male infants may have undescended testicles.</li>
<li>Trouble eating as an infant, with poor weight gain</li>
<li>Almond-shaped eyes</li>
<li>Delayed motor development</li>
<li>Narrow bifrontal skull</li>
<li>Excessive intake of food due to feeling of permanent hunger ; </li>
<li>Rapid weight gain ; ;</li>
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<p><a href="https://lh3.googleusercontent.com/-GLiS6PrF5U0/UYQ0_iz4lnI/AAAAAAAACAg/EKA3uIF75Pk/s640/blogger-image-1526176761.jpg" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img loading="lazy" border="0" height="257" src="https://lh3.googleusercontent.com/-GLiS6PrF5U0/UYQ0_iz4lnI/AAAAAAAACAg/EKA3uIF75Pk/s320/blogger-image-1526176761.jpg" width="320" /></a></p>
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<li>Short stature ;</li>
<li>Very small hands and feet in comparison to the child&#8217;s body.</li>
<li>Sex glands produce little or no hormones </li>
<li>Slow mental development. ;</li>
<li>learning difficulties </li>
<li>lack of secondary sexual development </li>
<li>behavioural problems, such as temper tantrums or stubbornness </li>
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<p>Children have an intense craving for food and will do almost anything to get it. This can result in uncontrollable weight gain and morbid obesity.</p></div>
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<div><b> ;Causes</b></div>
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<div>-Prader-Willi syndrome is caused by a gene missing on part of chromosome <span style="color: red;">15 </span>.Normally, each parents pass down a copy of this chromosome. Most patients with Prader-Willi syndrome are missing the genetic material on part of the father&#8217;s chromosome. Others often have <span style="color: red;">2 </span>copies of the mother&#8217;s chromosome 15. <br />The genetic changes occur randomly.</p>
<p>-Sufferes usually do not have a family history of the condition.<br /> ; <br /><a href="https://lh6.googleusercontent.com/-NvDWInhF8pM/UYTVa58OlAI/AAAAAAAACA8/gt5kQA1wr64/s640/blogger-image--728236369.jpg" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img loading="lazy" border="0" height="208" src="https://lh6.googleusercontent.com/-NvDWInhF8pM/UYTVa58OlAI/AAAAAAAACA8/gt5kQA1wr64/s400/blogger-image--728236369.jpg" width="400" /></a></p>
<p><b>Investigation </b></p>
<p>Genetic testing is available to test children for Prader-Willi syndrome.<br />As the child grows older, laboratory tests may show signs of morbid obesity, such as:</p>
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<div>Abnormal glucose tolerance</div>
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<div>Above normal level of the hormone insulin in the blood</div>
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<div>Decreased level of oxygen in the blood</div>
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<div>Failure to respond to luteinizing hormone releasing factor<b> ;</b></p>
<p><b>Management</b></div>
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<div>If a child with PWS follows a restricted diet and control their weight, they would be able to enjoy a good quality of life although, its highly unlikely that they lead a fully independent lives.</p>
<p><b>Heimlich manoeuvre</b>;a procedure for managing a chocking patient, is been taught to parents or guardians of patients because they are at high risk of choking as compulsive eating abnormally expands their stomach.</p>
<p>There is no cure for PWS, so treatment aims to manage the symptoms and associated problems. For parents, this includes ;dealing with ;their child&#8217;s behavioural problems and excessive eating.</p>
<p>Limiting calories will control the obesity, but the family, neighbors, and school must work together closely because the child will try to get food wherever possible. </p>
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<div>Growth hormone is approved by the Food and Drug Administration for the treatment of ;Prader-Willi syndrome. It can help:</p>
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<div>Improve physical strength and agility</div>
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<div>Improve height</div>
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<div>Increase lean muscle mass and decrease body fat</div>
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<div>Improve weight distribution</div>
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<div>Increase stamina</div>
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<div>Increase bone mineral density</div>
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<p>There have been some concerns that taking growth hormone therapy may lead to sleep apnea. A child who takes hormone therapy needs to have annual sleep studies to monitor for sleep apnea.<br />Low levels of sex hormones may be corrected at puberty with hormone replacement.<br /> ; </div>
<div><b>Complications</b></div>
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<div>Type 2 diabetes</div>
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<div>Right-sided heart failure</div>
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<div>Bone (orthopedic) problems.</p>
<p>This is a terrible health condition, at first parents would ensure that their children feed well and then try to restrain them from over eating. Lastly, they do not have a long life expectancy when compared to other children. </p></div>
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